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Acknowledgements The present study was funded by the National Research Foundation of Korea through the Basic Science Research Program (NRF-2017M3A9B4061890, NRF-2017R1D1A1B03035059, NRF-2017M3A9D8062960, and NRF-2018R1A2B3008541)

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S2a, b, 13, residues 175, blue) was the most affected by the mutation, with an RMSD exceeding 12 and subsequent stabilization after 17 s with fluctuations between ~2 and 8 (Supplementary Fig