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Transmission electron microscopy demonstrated that mitochondria presented considerable shrinkage with a ruptured outer mitochondrial membrane and reduced or disappeared mitochondrial cristae, similar to morphological characteristics of ferroptosis, in hyperosmolarity-induced HCECs

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whereas 40 MF were identified in which Organic cyclic compound binding (GO:0,097,159) was found with the lowest false discovery rate of 4.19E07 via the modulation of 27 targets (CDC34, ATP5F1B, CREBBP, PPARGC1A, NTRK2, HMGCR, MAP2K1, PRKDC, IDH2, PDE2A, MAP4K4, PRKAA1, NTRK3, PTGS1, HSD11B1, ADORA1, PRKAA2, HDAC1, FOXO1, ESRRB, SIRT3, CDK1, RELA, NTRK1, HIF1A, SOD2, IGF1R) against the 6050 background targets with a strength of 0.45

437 However, the combination of nifedipine and supplemental oxygen did not provide significant advantages over supplemental oxygen alone