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In vivo evaluation demonstrated that mice tolerated LAAM GSH-CQDs at doses up to 5000 mg kg 1 , compared to 18 mg kg 1 for LAAM TC-CQDs, 12 mg kg 1 for Lipo 2000, and 16 mg kg 1 for GO-CQDs

In addition to its benefits in inhibiting tumor growth, ACSL4-dependent ferroptosis is implicated in radiation-induced intestinal injury, a common gastrointestinal complication resulting from radiotherapy [185]

It has been confirmed to play a critical role in the development of various diseases, including cancer, neuropsychiatric disorders, and cardiovascular diseases [19]

RT and JP wrote the code and conducted the in silico experiments with HN and MR