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[137] The terms "CDR", and its plural "CDRs", refer to the complementarity determining region of which three make up the binding character of a light chain variable region (CDR-L1 , CDR-L2 and CDR-L3) and three make up the binding character of a heavy chain variable region (CDR-H1 , CDR-H2 and CDR-H3)

212 Under basal conditions, Keap1 forms a complex with Nrf2, leading to ubiquitination and subsequent degradation of Nrf2

Studies have shown that VIC is subject to zero-order to first-order pharmacokinetics, making it difficult to predict its possible effects, especially when high doses are administered [24,63,64]