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When excessive iron ions accumulate in cells, the resulting free Fe + triggers Fenton reactions that generate ROS

Pestic Biochem Physiol 55:1020 Google Scholar Baerson, SR, Sanchez-Moreiras, A, Pedrol-Bonjoch, N, Schulz, M, Kagan, IA, Agarwal, AK, Reigosa, MJ Duke, SO (2005) Detoxification and transcriptome response in Arabidopsis seedlings exposed to the allelochemical benzoxazolin-2(3H)-one

Am J Cardiol 94:384386

Compared with controls, SET significantly increased the 6-minute walk distance (6MWD), whereas peak oxygen consumption (VO 2 peak) increased by 14% from baseline, in contrast with a 0.2% decrease in the control group