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The malignant progression is accompanied with cytotoxicity decrease in NK cells and conversion to exhaustion due to changes in NK receptors, for example, the downregulation of NKG2D, NKp30, and DNAX accessory molecule-1 (DNAM-1) receptors

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However, the titers against Omicron BA.4/BA.5 were lower than against BA.1 for all candidate vaccines 43

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