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Heres what happens to rats when they eat megadoses of cysteine (5): We dont see a major effect until the dose reaches 1000 mg per kilogram of body weight

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At 428.203(b)(2)(i)(A) and (B), we proposed CMS will exclude 340B units beginning with January 1, 2026, which is the second calendar quarter in the applicable period starting October 1, 2025, and beyond (as discussed in further detail in section III.I.3.c.iv.2