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Five of the TAFs, namely TAF5, -6, -9, -10 and TAF12 are shared between TFIID and multifunctional SAGA complex (5-7)

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There is evidence that oxidative stress may reduce corticosteroid sensitivity in COPD by mechanisms involving phosphorylation of the glucocorticoid receptor (GR) as well as phosphorylation and inactivation of histone deacetylase-2 (HDAC-2) [38,39,40,41]

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