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Subsequently, we found that the thiol and amine can be added simultaneously to the BDA intermediate to still generate the same 3-thio N -pyrrole heterocycle 2a because of the high nucleophilicity of thiols as compared to amines (entry 3, Fig

[4] In patients with cyanide poisoning, hydroxocobalamin also acts as an antidote by binding to cyanide ions with high affinity to form nontoxic cyanocobalamin