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At steady state, however, cellular IL-1 expression is often undetectable and the ligation of pattern recognition receptors (PRR), such as Toll-like receptors (TLRs), is required to induce transcription of inactive pro-IL-1

Within this concentration range, NAC not only preserves the activity of seeding cells or in situ MSCs through enhancing proliferation and inhibiting apoptosis, but also significantly promotes the progression of stem cell osteogenesis (Table 1)