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Additional research, including studies from our collaborative research groups, has shown that severe reactive astrocytes exhibit the increased production of H 2 O 2 through MAO-B, leading to AD pathology hallmarks such as tauopathy, cognitive decline and neuronal atrophy 57

Forman HJ, Zhang H (2021) Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

SAMe acts as the body's universal "methyl donor," meaning it travels around the cell handing off methyl groups (a carbon atom attached to three hydrogen atoms) to various enzymes and proteins

Those chemicals together create sensations of warmth, of, uh, wellbeing, of safety