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Total (56% versus 50% of body weight) and extracellular body water (20% versus 15% of body weight), as well as exchangeable sodium, were shown to be increased in acromegalic patients compared to healthy subjects, whereas no differences were noted in intracellular water content [56, 101]

For example, a 12-month study in older adults found MK-677 raised IGF-1 to youthful levels and increased lean body mass , with participants gaining muscle instead of losing it all with no serious side effects noted