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DISCUSSION We describe the largest cohort of newly identified patients so far reported in the literature with a clinical and molecularly confirmed diagnosis of clEDS

Commonly reported side effects in research settings include: Nausea, particularly during dose-escalation phases

FDA data confirm that the most frequently cited GMP violations in inspections and warning letters consistently involve core quality system elements such as responsibilities of the quality control unit, production and process controls, laboratory controls, and production record review

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