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Acknowledgements The authors grateful the facilities of the Institute of Geophysics (UNAM-Mexico), as well as the academic support and collaboration of the National Autonomous University of Mexico and the National Autonomous University of Nicaragua (UNAN-Managua)

There is no identified upper limit for B12 as it's a water-soluble nutrient, meaning any excess is removed in urine

Then, the significance of the association was replicated in Anstee et al., GWAS (OR = 1.58

Potential concerns include: Unknown product quality Contamination or sterility issues Incorrect dosing Injection site reactions Allergic or immune reactions Medication interactions Hormonal or metabolic effects Unclear long-term safety Lack of monitoring Delayed treatment for an actual injury or medical condition Medical oversight is especially important for patients with autoimmune conditions, cancer history, active infections, chronic inflammatory disorders, cardiovascular concerns, hormone-sensitive conditions, or complex medication regimens