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Although TB m A-Glu exhibited excellent PDT efficiency in the subcutaneous tumor model, it is considered that the subcutaneous tumor model could not well simulate the actual characteristics of the tumor microenvironment 44,45

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Rapid phosphorylation of MAPKs also is a prerequisite for mechanosensitive gene expression 28 , as MPK3/MPK6 mediate the phosphorylation of mechanosensitive WRKY33 for its activation 58,59