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Mitochondrial dysfunction begins with the formation of drug-protein adducts between the reactive paracetamol metabolite, N-acetyl-p-benzoquinone imine (NAPQI), and mitochondrial proteins involved in the electron transport chain[22,23]

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The RNA-seq data of normal thyroid tissues were downloaded from the Genotype Tissue Expression (GTEx) database ( In addition, the study downloaded and integrated RRM2 RNA expression data for 30 different cancer types and their corresponding paracancerous tissues from the TCGA and GTEx databases