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However, the systemic introduction of ARA-290 in OIR mice seemed to lower the levels of pro-inflammatory cytokines like IL-1 and TNF- in the retinal tissue, hinting at its possible anti-inflammatory properties

Poe FL, Corn J

regulates tumor necrosis factor (TNF) and IL6 production posttranscriptionally by phosphorylating AUrich elements (AREs)binding proteins ELAVL1, HNRNPA0, PABPC1, and TTP/ZFP36, leading to increased stability and translation of TNF and IL6 mRNAs