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3.1 Chromosomally mediated resistance 3.1.1 Impaired fosfomycin uptake Mutations (such as insertions, deletions, or truncations) in the transporter-encoding genes glpT and uhpT result in impaired function or complete loss of the GlpT and UhpT transporters, respectively, thereby blocking or reducing fosfomycin uptake ( glpT , uhpT ) requires the presence of cAMP