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SAM synthesis from homocysteine requires methionine and various dietary precursors, such as choline and betaine (Zeisel 2009), with deficiencies impacting DNA methylation dynamics (Andreescu et al

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Untargeted lipidomics analysis of synovial fluid and serum from RA patients across various clinical stages, ranging from preclinical to active and sustained phases, showed that despite normal erythrocyte sedimentation rate and CRP at pre-clinical stages, the lipidomic profile of preclinical RA joint fluid closely resembled that of active RA (191)