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To check out this scenario, we analyzed the effect of zinc on axogenic and differentiative activity of recombinant PEDF under normal conditions and its prosurvival activity under stress conditions in appropriate cellular models, human neuroblastoma SH-SY5Y cells and Y79 cells 34,35,36

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The CNS is protected by the bloodbrain barrier (BBB), which complicates drug delivery for anti-inflammatory therapies [243, 244]

The in silico ADMET profiles for the top-ranked hits were predicted and the predicted non-toxic lead molecules showed the highest docking score in the range of 12.72 kcal/mol to 11.97 kcal/mol