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[cited 2025 Apr 18]

Relationship between oxidative stress and antioxidant systems in the liver of patients with Wilson disease: hepatic manifestation in Wilson disease as a consequence of augmented oxidative stress

Viability was measured using the MTT assay after 24 h exposure to each compound

Intracellular accumulation of Fe 2+ promotes lipid peroxidation and GSH depletion, ultimately leading to inactivation of GPx, impairing the cells ability to clear ROS and thereby initiating ferroptosis