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Specifically, the glutathionylation of Cys111 disrupts the dimer interface and yields SOD1 monomers that are significantly less active

The permeation enhancer may also be selected from any of the enhancing agents referred to in US 8,927,497, including in particular any of alkyl glycosides, any of the saccharide alkyl esters, and/or any of the mucosal delivery-enhancing agents described in this document