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Our results suggest that N-dealkylation may be an under-appreciated bioactivation pathway, especially in clinical contexts where aldehyde detoxification pathways are inhibited

This often leads to dysfunction because arginine residues, particularly those susceptible to modification, are found at functional sites of proteins 10

It is known that deficient metabolic control results in intense free radical production for a prolonged period of time, depleting the compensating capacity of the antioxidant enzyme systems and causing structural damage to the proteins exposed to advanced glycation products.21 Protein glycation not only affects hemoglobin but also proteins that participate in the host antioxidant defence systems, such as SOD, GPx and GRd, which act against ROS.22 Accordingly, poorly controlled diabetes with a glutathione system damaged by the inactivation of GPx and GRd could contribute to the development and/or progression of different complications of the disease.12,23 With regard to these complications, the main contribution of our study was the attempt to correlate this increase in salivary oxidative stress to the main oral manifestation of diabetes, periodontal disease

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