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Based on analyzing personal fitness levels, comorbidities, and preferences, customized exercise programs can be progressed to enhance advantages and lower risks (103, 104)

Sometimes, however, the production of ROS can exceed and overwhelm our antioxidant defences

These ROS generate hydroxyl radicals via the Fenton reaction, which attack intracellular proteins, DNA, and lipid membranes, thereby disrupting mitochondrial function and cellular integrity, and promoting the occurrence of ferroptosis

McMahon CD, Chai R, Radley-Crabb HG, Watson T, Matthews KG, Sheard PW, Soffe Z, Grounds MD, Shavlakadze T (2014) Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice