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However, research reports have confirmed that EVs can transfer the drug-resistant phenotype from drug-resistant cells to drug-sensitive cells in leukemia (303), breast cancer (304, 305), ovarian cancer (306), PC (307), CRC (308), and NSCLC (309)

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Apoptotic foci and altered tight junction protein expression damage the intestinal epithelium, enabling germs to get through, activating macrophages and antigen-presenting cells (APCs), and promoting the production of chemokines that attract neutrophils

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