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The BfR also recommends dividing the daily dose into at least two administrations per day, because in most studies used to determine the maximum intake, magnesium was consumed in two or more portions per day, which likely improves tolerability

[7] Within days, corneocyte cohesion decreases and comedonal plugs are extruded

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Drug development continues to face marked inefficiencies, with approximately 90% of drug candidates failing to reach approval despite extensive preclinical testing ( in vitro models, although cost-effective and suitable for high-throughput studies, lack the architectural complexity and biochemical microenvironment of human tissues