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Increased inflammatory cytokines including interleukins 6, 4 and 8, C-reactive protein, tumour necrosis factor , and transforming growth factor levels are correlated with worse motor function, whilst worse cognition is reported with higher levels of interleukins 6, 2, 8, 17, tumour necrosis factor , and C-reactive protein in several studies 193

Although some reports indicate that chronic (weeks to months) endurance exercise training does not increase SOD activity in muscle (10, 156, 229, 231), most studies conclude that regular bouts of endurance exercise increases the activities of both SOD1 and SOD2 in the exercised muscles (89, 165, 233, 237, 238, 288, 306, 307, 319, 404, 405)

10.34172/apb.2023.056 89 KimY