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doi: 10.3109/03009748009098150 122 LiaoKPPlayfordMPFritsMCoblynJSIannacconeCWeinblattMEet al

Interestingly, a positive feedback loop could also be established between p38 MAPK and oxidant species, since this kinase can promote the increase in ROS levels (Borodkina et al., 2014), and oxidant species have been shown to activate p38 MAPK in senescent cells (Marmisolle et al., 2017)

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Also, when blood-brain barrier (BBB) is disrupted by stroke and other brain diseases, it helps to transfer the systemic iron pool into neurons in the brain parenchyma, exacerbating ferroptosis (DeGregorio-Rocasolano et al., 2019)