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While risk estimates vary, associations are reported with all-cause mortality, colorectal and other carcinomas, atherosclerotic cardiovascular disease, type II diabetes, and possibly other inflammatory processes

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Although mitral valve repair or replacement would reduce both MR volume and prolapse volume, there are currently insufficient data to base surgical indications on total volume load instead of MR severity alone

Consequently, a significant difference of 16S rRNA microbial profiles was noted between low- and high-TMAO producing status ( p = 0.001, R 2 = 0.027) despite a small effect size (Fig