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These mice develop spontaneous GC in the absence of foreign antigen, increased numbers of T FH cells, spontaneous autoantibodies, including antinuclear antibodies, and lupus-like manifestations, such as glomerulonephritis

Because many tissues may have abundant D3 levels while the pituitary is uniquely void of D3, the inhibitory effects on the peripheral tissues causing hypothyroidism are not reflected by TSH testing (see Figures 2 and 3)