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There was a possible trend of a small decrease in eosinophils (-18%, p = 0.08), with initially 3/21 high, and only 2/21 high at the end of the study

Differential expression of ferritin-H and ferritin-L has been previously reported in the goblet, ciliated and basal subtypes airliquid interphase (ALI) cultured CF airway epithelial cells [53], suggesting that future studies of ferroptosis using ALI cultured cells may be able to explain the increased ferritin in IB3-1 cells

These milestone achievements in preclinical models provide robust support for the application of CAR T-cell therapy in autoimmune diseases and pave the way for subsequent clinical research and treatment

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