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in humans, microbial enzymes may degrade TCM metabolites before absorption, creating non-responders (Zimmermann et al., 2019). 6.6.2 Viable translational paths: to bridge this gap, we propose integrating the following strategies Clinical and Preclinical Alignment: Prioritize comparative functional indicators (e.g., targeted metabolite quantification, barrier markers like Zonulin/LPS) over mere taxonomic lists to enhance the testability of functional output in humans

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Clin Nutr ESPEN 13:e56 Shah S, Akbari M, Vanga R, Kelly CP, Hansen J, Theethira T, Tariq S, Dennis M, Leffler DA (2014) Patient perception of treatment burden is high in celiac disease compared with other common conditions

doi: 10.3390/foods9040481