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This result is due to the modification (s) in the present document which results in an increase of the dependence of the cofactor in comparison with the natural FXa or any variant of FXa existing in the art

132 WongJ

Even if the main folate receptors are blocked by antibodies, leucovorin can enter the central nervous system through the reduced folate carrier (RFC) , essentially bypassing the roadblock at the FR [4]

Lipid peroxides are primarily generated intracellularly through two processes: enzyme-catalyzed lipid peroxidation and the Fenton reaction induced by free iron ions