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The strategy adopted is reported in a recent paper (72)

MOUD have been shown to help people stay in treatment, and to reduce opioid use, opioid overdoses, and risks associated with opioid use disorder, including becoming infected with diseases transmitted by needles, such HIV and HCV.(21) Different levels of treatment may be needed by different individuals or at different times, including outpatient clinic, intensive outpatient treatment, inpatient (residential) treatment, or long-term therapeutic communities

Rodent behavioural paradigms (such as Morris water maze or novel object recognition) provide complementary in vivo endpoints for studying cognitive function-related signalling research questions.