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In contrast, in IFN-R / mice cuprizone-induced microglia accumulation was initially diminished or simply delayed (Mana et al., 2006) that was reflected at week 3 of cuprizone diet by a reduced expression of microglia-associated molecules such as IGF-1 and TNF- that have been proposed to promote proliferation of OPC

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Importantly, PDPN is upregulated in several types of cells during inflammation, including epithelial cells, fibroblasts, fibroblast-like reticular cells, APC and T helper cells interacting with several potential ligands, among which C-type lectin domain family 1 member B (CLEC1B/CLEC-2), CD44 and galectin 8 (274276)

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