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Researched for Preclinical (mouse-only) metabolic research as a selective inhibitor of NNMT (nicotinamide N-methyltransferase)

It is not FDA-approved for general weight loss, but can be used off-label in personalized medicine settings under provider supervision

However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

Jumping straight to the stack skips the dose-response curve for the better-studied compound and makes it impossible to attribute outcomes or adverse events to a specific agent