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N-acetylcysteine (NAC), the main contributor to maintain cellular GSH status, can minimize the oxidative effects of ROS by correcting or preventing GSH depletion [20,21,22,23]

Alternatively, there may be native FBXO22 substrates that are potentially recruited to the E3 ligase via engagement of Cys326 in a similar fashion to our NSD2 degraders that have not yet been uncovered