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In contrast, M2 macrophages produce cytokine signals like IL-6 and IL-10 that help cancer cells evade immune surveillance, recruit endothelial cells for angiogenesis, and avoid apoptosis, thus allowing them to proliferate more freely [146, 153]

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Executive Summary self-cleaves at the site between glycine (G) and praline (P by J Chng2015Cited by 225Self-cleavage of 2A peptides occurs between the last 2 amino acids, G and P