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Diseases associated with RAGE activation include inflammatory diseases, rheumatic or autoimmune diseases, infectious diseases, diabetes, metabolic syndrome and its complications, obesity, insulin resistance, hypertension, atherosclerosis, neurological diseases such as Alzheimers disease, cardiovascular diseases, pulmonary diseases such as chronic obstructive pulmonary disease (COPD), and cancer.[ref] (Yes, that is pretty much every chronic disease that I can think of and all are associated with aging.) Activation of RAGE (cell membrane receptor) causes an increase in reactive oxygen species as well as an increase in inflammatory cytokines

doi: 10.3390/md21070372 370 HartungNMFischerJOstermannAIWillenbergIRundKMSchebbNHet al

Targeting inhibitory neurotransmission in tinnitus

It sets the stage for all subsequent treatments