diethyl maleate glutathione depletion Diethylmaleate Hepatic transcriptome and proteome responses

Hepatic transcriptome and proteome responses against diethyl maleate induced glutathione depletion in the rat Archives of Toxicology Springer Nature Link The antioxidant glutathione plays a key role in protein folding The team discovered a few years ago that if glutathione levels aren't precisely maintained in mitochondria, all systems fail. On the heels Diethyl maleate inhibits MCA+TPA transformed cell growth via modulation of GSH, MAPK, and cancer pathways ScienceDirect AOP Wiki

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