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Although the reduction in sea ice area simulated in the warm composite and throughout the historical ensemble increases the proportion of winter precipitation, negatively influencing 18 O, less sea ice also shortens the distance between evaporation source and precipitation site, which has an opposing positive influence on 18 O

The EAR represents the level of vitamin B12 that is estimated to meet the B12 requirements of 50% of the healthy individuals in a particular sex and life-stage group

however, their immunosuppressive properties make their systemic use problematic and favour the use of calcineurin inhibitors in topical or device coating applications ( Figure 1 )

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