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Description

These changes further contribute to increased accessibility of oxidants to the membrane interior, which should further drive peroxidation

The Path of S-Acetyl-L-Glutathione: Prodrug Logic and Intracellular Activation S-Acetyl-L-glutathione employs an advanced prodrug design concept, effectively bypassing all delivery barriers encountered by GSH

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System Xc- mediates the uptake of cystine and the release of glutamate, thereby promoting the synthesis of GSH, which acts as a co-molecule with GPX-4 to assist in the scavenging of lipid peroxides to protect cells (Zhao et al., 2021)