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Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential

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Methylcobalamin is also contraindicated in patients with cobalt hypersensitivity because methylcobalamin contains cobalt

Jonathan Hommel for guidance in the original study design, and Dr