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In contrast, a resorcinyl-thiazole derivative, thiamidol, is a most potent inhibitor of human tyrosinase (IC 50 of 1.1 mol/L) but inhibits mushroom tyrosinase weakly (IC 50 = 108 mol/L) 130

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Thymosin beta 4: structure, function, and biological properties supporting current and future clinical applications

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Earlier biguanides such as phenformin and buformin showed greater potency but were withdrawn from the market due to a high incidence of lactic acidosis (LaMoia and Shulman, 2021)

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That said, the animal research is genuinely interesting and points toward several areas worth continued investigation

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