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LPS activating microglia via TLR4 as earlier described) [196]

An increased proportion of PUFAs in normal diet also induces oxidative stress (increased malondialdehyde [MDA]), reduces cellular defense against oxidative stress (metallothionein) in the liver, and promotes oxidative degradation of DNA (elevated 8-hydroxy-2-deoxyguanosine levels serum) in a content-dependent manner despite increased fat oxidation and decreased fat synthesis [80]