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Similarly, Dings research team engineered a system linking two shRNA transcription plasmids targeting MDR-related genes (P-glycoprotein and survivin) to doxorubicin (DOX)-loaded DNA origami via disulfide bonds [57]

These bioactive molecules specifically target and inhibit the cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) enzymatic pathways

Elegant review studies are already published elsewhere (Jiang and Cadenas, 2014

Additionally, the authors acknowledge the general positive bias of the published results, the lack of replicative validation studies, and the resulting risk of overestimating treatment efficacy in preclinical models that would provide confidence for the current findings and improve translational significance