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Eisai submitted a new drug application in May 2015 but the Pharmaceuticals and Medical Devices Agency (PMDA) indicated that additional clinical trials were necessary

Oil-based finishes are loaded with Volatile Organic Compounds (VOCs)

The most responsible framing is: Short-term tolerability is not the same as long-term safety Manufacturing quality heavily affects risk People with medical conditions or those taking medications should talk to a clinician before considering unapproved substances

The NHS treatment page lays it out clearly: Loading phase (no neurological symptoms): 1mg every other day for two weeks, or until symptoms stop improving