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Compared to rituximab, deeper B cell depletion is being explored with antibodies targeting CD20 (obinutuzumab), CD19 (inebilizumab), CD38 (daratumumab), the BAFF receptor (ianalumab), and TACI (telitacicept), as well as proteasome inhibition with bortezomib, all showing promise in IMIDs ( A key limitation of BCDA is the increased infection risk due to prolonged B-cell depletion, concurrent immunosuppressive therapy, and hypogammaglobulinemia ( Despite a plethora of successful targeted biologic therapies with different mechanisms of action, most patients with IMID still do not achieve remission, let alone drug-free remission ( 3 From stem cell therapy to targeted cell therapy for immune mediated inflammatory diseases 3.1 Transition from stem cell therapy to chimeric antigen receptor T cell therapy In contrast to the chronic immune suppression associated with targeted biologic therapies, stem cell treatments, including both mesenchymal stem cell therapy (MSCT) and hematopoietic stem cell therapy (HSCT)present a promising approach for potentially curing IMIDs by reinducing self-tolerance

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