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Several acidic metabolites produced by gut bacteria, like short chain fatty acids and lactic acids, can effectively lower gut luminal pH, which is conducive to reducing Fe 3+ within the gut lumen to more absorbable Fe 2+ (62, 63)

These markers are linked to one or more key physiological functions related to the immune system (glucose oxidase (GOX), phenoloxidase (POX) and alkaline phosphatase (ALP)), the xenobiotic detoxification system (glutathione-S-transferase (GST) and carboxylesterases 1, 2 & 3 (CaEs)), antioxidant defense (GST, glucose-6-phosphate dehydrogenase (G6PDH), catalase (CAT), glutathione peroxidase (GP), glutathione reductase (GR)), neural activity (acetylcholinesterase (AChE)) or metabolism (ALP, G6PDH, glyceraldehyde-3-phosphate dehydrogenase (GA3PDH), lactate dehydrogenase (LDH), adenosine triphosphate (ATP), CaE-1, CaE-2, CaE-3, GST) (Table 1)

S-0751 and Ethylenediaminetetraacetic Acid, Tetrasodium Salt, Sigma Stock No.ED4SS

Behrens IK, Busch B, Ishikawa-Ankerhold H, Palamides P, Shively JE, Stanners C, Chan C, Leung N, Gray-Owen S, Haas R (2020) The HopQ-CEACAM interaction controls CagA translocation, phosphorylation, and phagocytosis of Helicobacter pylori in neutrophils