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White Metallomics Research by Clare Duncan et al., published in Metallomics

To overcome the problem, prodrugs activated only after oral absorption were developed

Takeshima, Y., Iwasaki, Y., Fujio, K

Charges, coulombic and H-bonding interactions with neighboring functional groups In general, neighboring functional groups that stabilize the charge distribution of the transition state accelerate, and interactions that lower the energetics of the reactant complexes inhibit Reaction 1